[disclosure] History of Ketamine Therapy Ketamine, an NMDA receptor antagonist, was initially developed in the 1960s as an anesthetic agent. It was approved for medical use in the United States in 1970. In the 1990s, researchers discovered its potential antidepressant and anti-anxiety effects, which laid the foundation for ketamine therapy. Treatment-Resistant Depression and PTSD In … Continue reading Ketamine Therapy: History,Uses, and Comparisons